解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Genetic polymorphisms of interleukin-6 (IL-6) (-1363G>T, -597G>A, -572G>C, -174G>C, +2954G>C) may affect the outcomes of several diseases. This study was aimed to verify the role of these polymorphisms on the disease progression of patients with hepatitis C virus (HCV) infection and persistently normal transaminases (...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.06.006
更新日期:2010-10-01 00:00:00
abstract::The dendritic cell (DC) lineage encompasses a diverse population of cells with unique subtype-specific functions. In peripheral blood, four DC subsets have been identified based on their distinct expression of CD1c, CD141, CD16, and CD123, and these subpopulations exhibit functional properties in immune responses. How...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.07.008
更新日期:2010-10-01 00:00:00
abstract::The 5' cis-regulatory region of the CCR5 gene exhibits a strong signature of balancing selection in several human populations. Here we analyze the polymorphism of this region in Amerindians from Amazonia, who have a complex demographic history, including recent bottlenecks that are known to reduce genetic variability....
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.05.022
更新日期:2010-09-01 00:00:00
abstract::Intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) patients comprise at least 20% of treated patients and are at high risk for coronary artery abnormalities. If identified early in the course of the disease, such patients may benefit from additional anti-inflammatory therapy. The aim of this study was t...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.06.008
更新日期:2010-09-01 00:00:00
abstract::Human leukocyte antigen (HLA) antibodies are epitope specific and not antigen specific. This work presents a case of intra-allele (IA) sensitization. A 40-year-old-man underwent transplantion with identical "broad" DR. He was apparently not sensitized to HLA antigens by complement-dependent cytotoxicity (CDC), with on...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.05.018
更新日期:2010-09-01 00:00:00
abstract::Oxidized low-density lipoproteins and Toll-like receptors (TLR) 2 and 4 are involved in the development of atherosclerosis. The TLR are important in the pro-inflammatory response. The aim of this research was to analyze the activation of CD14, TLR4, and TLR2 in response to minimally modified low-density lipoprotein (m...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.05.005
更新日期:2010-08-01 00:00:00
abstract::This study investigated the association of rs7574865 polymorphism in STAT4 with Vogt-Koyanagi-Harada (VKH) syndrome and Behçet's disease (BD) in a Chinese Han population. Genotyping of rs7574865 polymorphism in the STAT4 gene was performed using polymerase chain reaction restriction fragment length polymorphisms in 37...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.04.007
更新日期:2010-07-01 00:00:00
abstract::Immune thrombocytopenia (ITP) is an acquired organ-specific autoimmune disease with a polarization of T(h)1. Both the T(h)1 chemokine CXCL10 and T(h)2 chemokine CCL2 have been studied in several autoimmune diseases, but the status of these chemokines in ITP is still unknown. The aims of this study were to determine th...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.02.010
更新日期:2010-06-01 00:00:00
abstract::NKG2D is an important activating receptor on NK cells and T-cells and has a diverse panel of ligands (NKG2DL) which include the ULBP and RAET1 proteins. Several NKG2DL exhibit a considerable degree of genetic polymorphism, and although the functional significance of such allelic variation remains unclear, genetic vari...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.02.018
更新日期:2010-06-01 00:00:00
abstract::The aim of this study was to determine the prognostic significance of soluble human leukocyte antigen (HLA) class I (sHLA-I) and HLA-G molecules in lung cancer patients. A total of 23 small-cell lung cancer (SCLC) and 114 non-small-cell lung cancer (NSCLC) patients, including 55 adenocarcinoma, 46 squamous cell carcin...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.02.015
更新日期:2010-05-01 00:00:00
abstract::Alloantibodies are known to influence transplant outcomes. Apart from human leukocyte antigens (HLA), non-HLA targets have been suggested to play a significant role, but little is known about their nature. Here, we present a novel method for identification and characterization of cell surface antigens bound by allorea...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.02.006
更新日期:2010-05-01 00:00:00
abstract::Toll-like receptors (TLRs) are important in the initiation of immune responses in both health and disease. How TLR activity alters with age, gender, and also with immunosuppressive agents is still largely unexplored. We studied TLR activity in 49 healthy individuals as well as in 26 patients receiving immunosuppressiv...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.01.018
更新日期:2010-04-01 00:00:00
abstract::Mannose-binding lectin (MBL) is a major, soluble, pattern-recognition molecule and an important component of the innate host defense. The role of MBL in inflammatory bowel diseases (IBDs) is controversial. We determined the prevalence of MBL deficiency in a Hungarian IBD patients' cohort, and whether it is associated ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.01.012
更新日期:2010-04-01 00:00:00
abstract::Polymorphisms of interleukin-23 receptor (IL23R) gene have recently been reported to be associated with the susceptibility to several immune-related diseases. The aim of this study was to determine the association of IL23R polymorphisms with Vogt-Koyanagi-Harada (VKH) syndrome, a disease presumably mediated by autoimm...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.01.026
更新日期:2010-04-01 00:00:00
abstract::Mannose-binding lectin (MBL) role in the carriage of oropharyngeal bacteria is not known. We investigated the association of smoking, MBL2 polymorphisms, and MBL concentrations with oropharyngeal carriage of respiratory bacteria in young men. Oropharyngeal specimens, MBL concentrations, and MBL2 gene polymorphisms wer...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.12.009
更新日期:2010-03-01 00:00:00
abstract::In this study, we evaluated the leukocyte density and composition in the human cycling endometrium with uterine fibroids (UF). The endometrium with neighboring nodule (NN group, n = 62), autologous endometrium without NN (non-NN group, n = 62), and allogeneic endometrium without UF (non-UF group, n = 24) were immunost...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.11.014
更新日期:2010-02-01 00:00:00
abstract::Invariant natural killer T (iNKT) cells have been reported to play a role in the pathogenesis of murine asthma. However, the role for iNKT cells in the pathogenesis of human asthma is not defined. In this study we aimed to determined how blood iNKT cells are associated with atopy in asthmatic individuals. Peripheral b...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.10.011
更新日期:2010-02-01 00:00:00
abstract::Dendritic cells (DCs) exposed to tumor antigens followed by treatment with T(h)1-polarizing differentiation signals have paved the way for the development of DC-based cancer vaccines. Critical parameters for assessment of the optimal functional state of DCs and prediction of the vaccine potency of activated DCs have i...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.10.001
更新日期:2010-01-01 00:00:00
abstract::Novel therapeutic strategies such as the modulation of dendritic cell and T-cell function have exhibited great potential in clinical transplantation. Human leukocyte antigen (HLA)-G is a molecule that plays a significant role in establishing complex mechanisms to protect semiallogeneic fetuses from rejection by the ma...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.07.023
更新日期:2009-12-01 00:00:00
abstract::Human leukocyte antigen-G (HLA-G) is a nonclassical class Ib molecule belonging to the major histocompatibility complex. HLA-G appears to play a role in the suppression of immune responses and contribute to long-term immune escape or tolerance. The focus of this review is polymorphism in the HLA-G gene and protein and...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2009.07.015
更新日期:2009-12-01 00:00:00
abstract::Human leukocyte antigen-G (HLA-G) is a nonclassical tolerogenic molecule that can be expressed either as membrane bound (HLA-G1) or secreted (HLA-G5) isoforms. Upregulation of HLA-G1 or HLA-G5 expression by tumor cells constitutes an efficient way to escape from antitumoral immune responses. The inhibitory role of HLA...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.07.019
更新日期:2009-12-01 00:00:00
abstract::Glucocorticoids are widely used for their anti-inflammatory and immunosuppressive properties. Changing concentrations of transcriptional cofactors or chemicals in transiently transfected tissue culture cells modify several properties of glucocorticoid receptor-regulated gene expression including total activity (A(max)...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.07.029
更新日期:2009-10-01 00:00:00
abstract::The presence of complement fixing anti-human leukocyte antigen (HLA) antibodies in the circulation of organ transplant recipients may result in heart allograft rejection. Here, we assessed the clinical impact of pre- and post-transplantation allosensitization on long-term survival of heart allografts. Sequential sampl...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.06.015
更新日期:2009-10-01 00:00:00
abstract::The 14-base pair (bp) polymorphism within the HLA-G gene has been investigated in heart transplant patients for the first time. The 14-bp polymorphism is associated with HLA-G mRNA stability and the patterns of alternative isoforms splicing, and therefore may influence the functionality of the HLA-G molecule. In heart...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.07.012
更新日期:2009-10-01 00:00:00
abstract::Previously, most models that sought to explain the misregulation of immune cell function assumed molecular similarities between the disease-causing pathogens and the host's proteins. In recent time several different models have been proposed and in this study, these concepts are compared to a new hypothesis proposing ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.05.010
更新日期:2009-09-01 00:00:00
abstract::It has been suggested that MEVF mutations offer advantage against infections, including tuberculosis. Bearing in mind the central role of TLR-2 and TLR-4 in the recognition of pathogens, we conducted this study to examine whether the TLR2-R753Q, TLR4-D299G, TLR4-T399I common polymorphisms are associated with susceptib...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.05.004
更新日期:2009-09-01 00:00:00
abstract::Preformed and de novo donor-specific HLA antibodies (DSA) have been associated with allograft dysfunction and failure. The application of solid-phase methods have increased the sensitivity and specificity of antibody detection; however the clinical significance of these DSA is under evaluation. In the present study, w...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.06.009
更新日期:2009-08-01 00:00:00
abstract::Presensitizing alloantibodies may represent a grave danger in organ transplantation, increasing the risk of antibody-mediated rejection (AMR) and graft loss. However, not all antibodies are harmful to the graft. In our study of a cohort of 325 deceased-donor renal allograft recipients, the patients were determined eli...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.04.018
更新日期:2009-08-01 00:00:00
abstract::Bacterial sensing is crucial for appropriate response by the innate and adaptive immune system against invading microorganisms. Single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition, CARD15 and TLR4, increased the risk of inflammatory bowel disease (IBD) in a New Zealand Caucasian case-cont...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.03.002
更新日期:2009-06-01 00:00:00
abstract::FOXP3(+) regulatory T cells, a unique subset of T cells, are critical for orchestrating an immune response and preventing self-reactivity. With the increasing prevalence and unsatisfactory treatment of autoimmunity, allergic diseases, cancer and chronic infections, much attention has been focused on understanding thei...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2009.02.007
更新日期:2009-05-01 00:00:00
abstract::Complement receptor 1 (CR1/CD35) levels on erythrocytes and related CR1 polymorphisms have been associated with response to falciparum malaria in populations inhabiting malaria-endemic regions. Differences in disease association profiles of its low expression alleles have been observed in populations from different re...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.02.001
更新日期:2009-04-01 00:00:00
abstract::To commence proper antibiotic treatment in sepsis, timely knowledge of whether the cause of systemic infection is gram-negative (gram(-)) or gram-positive (gram(+)) bacteria in origin would be beneficial for clinicians. In this clinical prospective study, our objective was to develop a method for distinguishing betwee...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.01.009
更新日期:2009-04-01 00:00:00
abstract::Early allograft function after lung transplantation is variable. Clinical criteria have limited predictive value for early graft function. Recipient immunologic state before LTx may affect early lung function. We investigated the association between pretransplantation soluble CD30 (sCD30), a marker of Th2-type T-cell ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2008.12.005
更新日期:2009-02-01 00:00:00
abstract::This study examined the performance of a tuberculosis (TB)-specific enzyme-linked immunospot assay in 48 patients awaiting liver transplantation. They were tested with T-SPOT.TB, tuberculin skin test (TST), and lymphocyte transformation test (LTT) using tuberculin as a stimulus. A questionnaire was used to gain inform...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2008.10.005
更新日期:2009-01-01 00:00:00
abstract::The objective of this study was to investigate whether there is an association between IL1RN polymorphism and disease susceptibility for three age-related inflammatory conditions: polymyalgia rheumatica (PMR), giant cell arteritis (GCA), and elderly-onset rheumatoid arthritis (EORA). A tandem-repeat polymorphism withi...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2008.10.011
更新日期:2009-01-01 00:00:00
abstract::Recent studies have suggested a clinical significance to the detection of anti-major histocompatibility complex class I-related chain A (MICA) antibodies in transplantation. We have developed an eplet-based version of the HLAMatchmaker algorithm to assess the epitope specificity of these antibodies. Molecular viewing ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2008.10.003
更新日期:2008-12-01 00:00:00
abstract::Regulatory T cells (T(reg) cells) play an important role in the regulation and suppression of immune responses to self- and foreign antigens. Suppressed and impaired host immune responses are a major characteristic of many persistent human virus infections, such as those caused by human immunodeficiency virus (HIV), h...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2008.07.016
更新日期:2008-11-01 00:00:00
abstract::This review focuses on the role of antigen-specific T cells that mediate active inhibition of immune responses over the past 35 years since their initial description. The field has experienced several changes in the accepted paradigm of such suppressor/regulatory T cells, from initial indications that such cells were ...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2008.07.018
更新日期:2008-11-01 00:00:00
abstract::Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) of putative autoimmune origin. Recent evidence indicates that MS autoimmunity is linked to defects in regulatory T-cell function, which normally regulates immune responses to self-antigens and prevents autoimmune disea...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2008.07.014
更新日期:2008-11-01 00:00:00
abstract::By discriminating self from nonself and controlling the magnitude and class of immune responses, the immune system mounts effective immunity against virtually any foreign antigens but avoids harmful immune responses to self. These are two equally important and related but distinct processes, which function in concert ...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2008.08.279
更新日期:2008-11-01 00:00:00